Punicalagin and ellagic acid containing Punica granatum L. fruit rind extract prevents vincristine-induced neuropathic pain in rats: an in silico and in vivo evidence of GABAergic action and cytokine inhibition.

Vivek Jain,Ashutosh Pareek,Yashumati Ratan Bhardwaj,Saurabh K. Sinha,Madan Mohan Gupta,Nirmal Singh

Punicalagin and ellagic acid containing Punica granatum L. fruit rind extract prevents vincristine-induced neuropathic pain in rats: an in silico and in vivo evidence of GABAergic action and cytokine inhibition.

2021

Vivek Jain
Ashutosh Pareek
Yashumati Ratan Bhardwaj
Saurabh K. Sinha
Madan Mohan Gupta
Nirmal Singh

Objectives: We aimed to investigate the protective potential of Punica granatum L. fruit rind extract (PFE) containing punicalagin (10.3% W/W), ellagic acid (EA) (2.7%W/W) in vincristine (75 µg/kg ...

Keywords:

Cytokine
Pharmacology
Vincristine
Interleukin 6
Punica
Ellagic acid
In vivo
Punicalagin
Chemistry
Neuropathic pain

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