Sesamolinol glucoside and other lignans from Sesame seeds with antimutagenic and lipid peroxidation inhibitory activities

Following our previous work on sesame testa [1], we applied a procedure based on XAD-4 adsorption resin, which permits the obtainment of an enriched polyphenolic extracts from Sesamum indicum seeds. Chemical analysis of the obtained extract led to the identification of twelve lignans. Among them, a new lignan, (+)-sesamolinol-4-O-β-D-glucoside (1), has been isolated and its structure determined by spectroscopic methods, mainly by the concerted application of 1D and 2D NMR techniques (HMQC, HMBC, NOESY) and mass spectroscopy. Some of the isolated compounds were evaluated for their antimutagenic and lipid peroxidation inhibitory activities. Acknowledgement: The project was funded by the General Secreteriat for Research and Technology of Greece (Program 05ΔΣEBΠPO-113) Reference: 1. Grougnet; R. et al (2006)J. Agric. Food Chem. 54: 7570–7574.