TISSUE REACTIONS TO VARIOUS PERCUTANEOUS MATERIALS WITH DIFFERENT SURFACE PROPERTIES AND STRUCTURES

: Tissue responses to various percutaneous materials with different surface properties and structures were investigated. Dense hydroxyapatite (HA), tricalcium phosphate (TCP), glassy carbon (GC), and 2 types of porous HA were used. Cutaneous and subcutaneous tissues were tightly attached to the surface of the penetrating portion of an HA percutaneous device (PD). Neither bacterial infection nor serious epidermal downgrowth were observed in the area surrounding the shaft of the HA-PD. At the margin of the epidermis, fibroblasts and collagen fibrils of fibrous connective tissue were well oriented and formed perpendicular to the shaft. The tissue response to the TCP was mild and nearly the same as that to the HA. The GC induced serious epidermal downgrowth and inflammatory cell infiltration. In contrast to dense HA-PD, the insertion of both types of porous HA-PDs, 1 with a spongy structure and 1 with close pores was followed by acute infection within 1 month. Based upon these results, it was concluded that the dense HA was the best percutaneous material of those tested.