The extract from the tissue of gastric cancer as procoagulant in disseminated intravascular coagulation syndrome.

Abstract Tissue extracts from two histopathologic types of surgically removed gastric cancer were investigated for procoagulant and fibrinolytic activities. Procoagulant activity was found to be due to a thromboplastin-like substance; 1 mg of the extract protein was equivalent to 0.014 mg of Lyoplastin (thromboplastin). It is inhibited by heparin, Trasylol and is partially inactivated by heating at 100°C for 10 min, but not at 56°C and 37°C. The extracts had both plasminogen activator and plasmin activities. The fibrinolytic activity was inhibited by soybean trypsin inhibitor, Trasylol, and t-AMCHA. In 12 cases studied, nine were of adenocarcinoma and three were carcinoma simplex. Both procoagulant and fibrinolytic activities appeared to be greatest in the extracts from adenocarcinoma, as compared to those from carcinoma simplex or the normal tissue surrounding the lesions.