Comparative Study on Different Dosages of Butorphanol for Postoperative PCIA in Patient with Thoracic Surgery

Objective To compare the effect and safety of different dosages of butorphanol for patient-controlled intravenous analgesia (PCIA) for thoracic surgery.Methods 90 patients scheduled for elective thoracic surgery were randomly divided into group B1 (butorphanol 8mg),group B2 (butorphanol 10mg),group B3 (butorphanol 12mg) for PCIA.The respiratory rate (RR),heart rate (HR),blood pressure (BP),SpO 2 and VAS,Ramsay,BCS score and adverse reaction before and after the operation were recorded.Results Compared with group B1 and B2,the RR,SpO2 of group B3 at postoperative 1,4 h had decreased in different degree (P0.05),but still in the safe range.Satisfactory analgesia were achieved in all of 3 groups,VAS score B3B2B1 (P0.05).The Ramsay score of group B3 at postoperative 1,4,8 h were significantly higher than group B1 and B2.BCS score:B3B2B1 (P 0.05).The incidence of nausea and vomiting,dizziness in group B3 were significantly higher than group B1 and B2 (P0.05).Conclusions Satisfactory analgesia can be achieved in 3 different dosages of butorphanol for PCIA in patients with thoracic surgery,but the formula of 10mg/100mL is more safe and comfortable.