Choroidal anatomical alterations following photodynamic therapy for chronic central serous chorioretinopathy: a multicenter study.

Abstract Purpose To study the early anatomical choroidal alterations in eyes with chronic central serous chorioretinopathy (CSCR) undergoing photodynamic therapy (PDT). Design Multicenter retrospective cohort study. Methods A total of 77 patients and 81 eyes with chronic CSCR treated with PDT and 64 untreated fellow eyes were evaluated. Central macular thickness (CMT), and choroidal features including subfoveal choroidal thickness (SFCT), total choroidal area (TCA), luminal choroidal area (LCA) and stromal choroidal area (SCA) were analyzed. Choroidal vascularity index (CVI) was calculated in all study eyes at baseline, and at 1- and 3-months post-PDT. Results In eyes receiving PDT, Snellen visual acuity (VA) significantly improved at months 1 and 3 (p p visit, respectively (p=0.01). No significant changes were recorded for SCA and CVI. In the fellow eye group, VA, CMT, and all choroidal parameters showed no differences between baseline and any follow up visits (all p>0.05). Conclusions Following PDT for chronic CSCR, we observed sustained reductions in CMT and SFCT, while reductions in TCA and LCA were only noted at the 1-month follow up interval. These choroidal parameters may provide additional quantitative biomarkers to evaluate anatomical response to therapy but awaits further prospective validation.