Findings in normal rats following administration of gliadorphin-7 (GD-7)

This paper discusses the effects of gliadorphin-7 (GD-7) infusion in rats and contrasts them with those of β-casomorphin-7 (βC-7). Both induce FLI in a dose related fashion. Very strong expression in both geniculate nuclei (GN) and the alveus hippocampus follow GD-7 400 μg and βC-7 30 μg/kg BW. GD-7 affects only these three regions while βC-7affects 45. FLI is prevented by Naloxone 2 mg/kg BW in all regions except the GN where it is diminished 60%. βC-7 causes bizarre behavior beginning 60 s after infusion is started. GD-7 causes no behavioral change. These findings suggest GD-7 gains access to brain cells by diffusion through circumventricular organs while βC-7 passes the BBB by carrier facilitation.