A CASE REPORT OF MULLERIAN ADENOSARCOMA WITH HETEROGONOUS ELEMENTS ASSOCIATED WITH LONG-TERM ORAL CONTRACEPTIVE USE

Introduction: Adenosarcoma is a rare uterine tumor composed of benign epithelial and malignant stromal elements. In 20% of cases stroma contains heterologous elements (usually from stratified muscle type). Association between Tamoxifen usage (exogenous strogen) or ovarian thecoma (endogenous strogen) and occurance of this tumor has been reported. This is a case report of a uterine Adenosarcoma. Case: The patient was a 45 years old woman with history of 16 years OCP use who was admitted with a uterine mass and undergone total hysterectomy. Microscopic assessment of slides, stained by H&A, was indicator of Adenosarcoma with cartilage heterologous elements. Conclusion: Uterine Adenosarcoma is a rare tumor. Although there is a few reports of cartilage heterologous elements in uterine Adenosarcoma, this case had multiple cartilage points in stroma. Also in this case, the coexistance of this tumor with longterm OCP use was considerable. Key word: Malignant mixed mullerian tumor, uterine Adenosarcoma, heterologous elements, OCP 5 Associate professr of pathology, Isfahan University of medical sciences. 6 Assistant professor of pathology, Isfahan University of medical sciences. 7 Resident of pathology, Isfahan University of medical sciences. 8 Assistant professor, gynecologist, Isfahan University of medical sciences.