Vaginal mucosal immunization for recurrent urinary tract infection : Extended phase II clinical trial
2001
Many women remain susceptible to ascending urinary tract infections (UTIs) despite the absence of a demonstrable anatomic abnormality [1]. Repeated treatment with antibiotics is often necessary for these women but may lead to adverse reactions and infection with antibiotic-resistant organisms [2]. On the basis of concepts of mucosal immunity in the genitourinary tract [3-5], we have been working to develop an effective mucosally applied vaginal immunogen to help prevent ascending UTIs. After a trial in nonhuman primates, we carried out and reported two previous clinical trials in susceptible women [6-8]. We are now reporting on a clinical trial to extend the time period of protection through use of the same multivalent vaginal immunogen and through immunogen boosts given at 4week intervals.
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