Содержание матриксных металлопротеиназ 2; 7 и 9 в опухолях и сыворотке крови больных раком молочной железы

A significant increase of matrix metalloproteinases’ (MMP) 2 and 7 levels in the tumors as compared to adjacent histologically unchanged mammary gland was demonstrated by enzyme-linked immunosorbent assays in 91 and 76% of breast cancer patients respectively, while MMP-9 levels in these tissues did not differ significantly. The concentrations of MMP-2 and MMP-7 in blood serum were not associated with corresponding tumor values, did not exceed the control levels, and did not decrease after the excision of primary tumor. Serum MMP-9 was significantly decreased in breast cancer patients as compared to control group, and increased post-surgically in 85% of the patients. No unambiguous associations between the parameters studied and breast cancer clinico-morphologic prognostic factors were revealed.