P.1.b.016 The effect of the FGL peptide on quantitative EEG in an animal model of Alzheimer's disease

of results: While there was no change in any of the parameters measured in the open field test, the administration of THC disrupted prepulse inhibition of acoustic startle reaction. The most prominent changes were noted for all doses for the 83 dB intensity and 120ms prepulse-pulse interval (p< 0.05), furthermore for the dose of 1mg/kg of the same intensity and 30ms interval (p< 0.01). In the EEG experiments the mean absolute power spectra showed no significant change but the relative power spectra revealed a power decrease in the low-gamma band 1 hour after administration (p< 0.001). There was also a trend that indicated a mild decrease in power in the delta/theta frequency band and an increase in the alpha/beta frequency band. EEG coherence showed a decrease in connectivity in the delta to beta frequency bands while there was an increase in the high beta and low-gamma bands. Conclusions: Even though THC did not induce hyperlocomotion, which is believed to model positive symptoms [1], it disrupted sensorimotor gating indicating some similarity to other models of psychosis and schizophrenic patients [2]. The altered gamma activity and decreased connectivity that were mainly found in our model are also in line with findings in schizophrenia and other models [3]. While the resulting changes in power spectra from the EEG part of the study are specific for different models, a relatively constant finding across models is the decrease in functional connectivity typically found in schizophrenic patients. Thus in conclusion, our results support the hypothesis that some aspects of THC induced changes can serve as a model of psychosis in rats.