Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors

The shuttling of AMPA receptors to and from the synaptic membrane determines the strength of synaptic transmission. This study shows that ephrinB2 is part of the mechanism that stabilizes AMPA receptors at the synaptic surface. EphrinB2 and AMPA receptors are linked by two PDZ domains in the intracellular adaptor protein GRIP.