Double-alkoxy pyrimidine jointing 3-ethylenic-bond-oxoindole derivative and preparing method and application thereof

The invention discloses a double-alkoxy pyrimidine jointing 3-ethylenic-bond-oxoindole derivative. A preparing method includes the steps that different-substitution 2-indolone and different-substitution 3,5-dichloropyrimidine formaldehyde are subjected to heating reflux in an alcohols solvent under the inorganic alkaline condition, are subjected to a Knoevenagel addition-elimination reaction, and are subjected to an alcoholic-hydroxyl-group dual-substitution helium-atom reaction, and the double-alkoxy pyrimidine jointing 3-ethylenic-bond-oxoindole derivative is obtained. Skeletons include the potential biological-activity pyrimidine skeletons and the 3-ethylenic-bond-oxoindole skeletons. The double-alkoxy pyrimidine jointing 3-ethylenic-bond-oxoindole derivative is an important medical-intermediate analogue and a drug-molecule analogue, can provide compound sources for biological-activity screening, and has an important application value for drug screening and the pharmaceutical industry; according to the derivative, two tumor cell lines are subjected to tumor-growth-inhibitory activity screening, and it is proved that the derivatives have certain tumor-cell-growth-inhibitory activity, and can be expected to serve as an antineoplastic drug.