Optical resolution by electrokinetic chromatography using ovomucoid as a pseudo-stationary phase

The utilization of ovomucoid as a chiral pseudo-stationary phase in electrokinetic chromatography was studied. Optical resolution of some drugs was achieved successfully with high efficiency by optimizing the concentrations of both ovomucoid and an organic solvent. The reproducibility was improved by the addition of cellulose derivatives to the separation solutions or by using coated capillaries. This approach is expected to have wide applications.