Effects of Exogenous PQQ on Mortality Rate and Some Biochemical Parameters During Endotoxin Shock in Rats

Effects of exogenously administered PQQ on mortality rate and some biochemical and hematological parameters were studied in rats during endotoxin shock induced by a E. coli toxin. PQQ administration (6mg/kg i.p.) reduced their mortality rate from 68.8% to 28.6%. Aspartate aminotransferase (GOT), alanine aminotransferase(GPT), blood urea nitrogen(BUN), uric acid, lipoperoxide and calcium in rat sera were all improved by PQQ administration platelet counts, prothrombin time(PT), and antithrombin III (AT III) were also improved markedly.