Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study

Background Prevalence of anxiety and depression is high in people with Primary Sjogren’s syndrome (pSS). However, there are currently no known reported studies about anxiety/depression in pSS patients from China. Our aim was to compare anxiety/depression in pSS patients and healthy controls; to investigate the prevalence of anxiety and/or depression among pSS patients in China; to evaluate its relationship with the disease activity, fatigue, pain, education, ocular surface disease, oral health, swallowing disorders, employment status, European League Against Rheumatism Sjogren’s Syndrome Patient Reported Index(ESSPRI) as well as to analyze potential determinants of anxiety and depression.