Enhanced antibacterial activity of silica nanorattles with ZnO combination nanoparticles against methicillin-resistant Staphylococcus aureus
2017
Silica nanorattles (SNs) with zinc oxide (ZnO) combination nanoparticles
are reported to inhibit methicillin-resistant Staphylococcus aureus
(MRSA) for the first time. SNs loaded with ZnO nanoparticles, which
can produce free radicals, can cause severe damage to bacteria. ZnO
nanoparticles not only provide free radicals in the combined nanostructures,
which can inhibit the growth of bacteria, but also form nanorough
surfaces with an irregular distribution of spikes on the SNs, which
can enhance their adhesion to bacteria. Nanorough silica shell surfaces
maintain the high activity and stability of small-sized ZnO nanoparticles
and gather ZnO nanoparticles together to enhance production, which
improves the efficiency of free radicals against the cytomembranes
of bacterial cells. The enhanced adhesion of ZnO@SN nanoparticles
to MRSA cells shortens the effective touching distance between free
radicals and MRSA, which also improves antibacterial activity. As
we expected, the ZnO@SN nanoparticles exhibit a better antibacterial
effect than free ZnO nanoparticles against MRSA in vitro and in vivo.
We also demonstrate that SNs loaded with ZnO nanoparticles can accelerate
wound healing in MRSA skin inflammation models. This method of multilevel
functionalization will be potentially applicable to the antibacterial
field.
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