Changes of Receptors

Chronic fluorosis is an endemic disease that severely impairs human health. Studies have proved that the change of various receptors in the body is attributed to excessive fluoride intake. For instance, it will reduce the expression of acetylcholine receptor that affects the release of neurotransmitters and will cause changes of N-methyl-D-aspartic acid receptor that impacts cellular Ca2+ influx and of advanced glycation end product receptor, augmenting the inflammatory response of the body, etc. These changes are the key mechanism of multi-system injuries caused by fluorosis. With the increased attention on more and more receptors in recent years, the role they played in the pathogenesis of chronic fluorosis is becoming ever more essential. Therefore, an in-depth study of its mechanism of action is possibly vital to uncover the injury of chronic fluorosis and can also provide a theoretical basis for prevention and clinical treatments.