Normal β-Cell Function in Post-Liver Transplantation Diabetes Treated With Tacrolimus

Use of immunosuppressive agents is mandatory after organ transplantations but may be complicated by the development of hyperglycemia or diabetes. The prevalence of diabetes after liver transplantation in adulthood ranges from 13.6 to 33% (1,2) with a progressive increase in risk that parallels the time after transplant (3). Tacrolimus, a calcineurin inhibitor, is a recent immunosuppressive agent largely used to prevent and treat transplant rejections often following other immunosuppressive failures (4–5). The incidence of post-transplant diabetes mellitus (PTDM) in tacrolimus-treated patients was significantly higher than in those treated with …