Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation

Johann Greil,Maria V. Verga-Falzacappa,Nicole Echner,Wolfgang Behnisch,Obul R. Bandapalli,Paulina Pechanska,Stephan Immenschuh,Vijith Vijayan,József Balla,Hirokatsu Tsukahara,Marion Schneider,Gritta Janka,Maren Claus,T. Longerich,Martina U. Muckenthaler,Andreas E. Kulozik

Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation

2016

Johann Greil
Maria V. Verga-Falzacappa
Nicole Echner
Wolfgang Behnisch
Obul R. Bandapalli
Paulina Pechanska
Stephan Immenschuh
Vijith Vijayan
József Balla
Hirokatsu Tsukahara
Marion Schneider
Gritta Janka
Maren Claus
T. Longerich
Martina U. Muckenthaler
Andreas E. Kulozik

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder characterized by fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypercytokinemia, and hemophagocytosis. The genetically determined forms of HLH, also referred to as familial hemophagocytic lymphohistiocytosis,

Keywords:

Immunology
Hypertriglyceridemia
Heme oxygenase
Hemophagocytic lymphohistiocytosis
Microcytic anemia
Hepatosplenomegaly
Familial Hemophagocytic Lymphohistiocytosis
Cytopenia
Medicine
Hemophagocytosis

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