신장이식 344례의 임상적 고찰 - 다기관 분석 -

With the development of immunosuppressive agents, renal transplantation is now the treatment of choice for many patients with end stage renal disease, although hemodialysis and peritoneal dialysis serve as an adequate substitute for most patients. There was no nationalized organ sharing system in Korea like UNOS(United Network of Organ Sharing) in America and a little communication among the transplantation hospitals. On the base of these, we attemt multicenter study first in Korea. In the period from July 1987 to September 1996, 344 consecutive patients who received renal transplants for end stage renal disease were analyzed with Cox regression model at Chonnam, Chonbuk, and Wonkwang University Hospitals. The risk variables screened included age and sex of recipient, donor-recipient relationship, age of donor, multiplicity of donor artery, ABO and HLA compatibility, HBsAg, lymphocyte cross matching test, method and duration of dialysis, donor specific transfusion, immunosuppressive drug protocol, urine amount, value of BUN and serum creatinine at 1st week, episode of acute and chronic rejection, and complication. Graft surival was 91.4% at 1 year, 85.3% at 2 years and 72.8% at 5 years. The important risk factors that reduce renal allograft functional survial included sex of recipient, single donor artery, urine amount and value of serum creatinine at 1st week, and complication. (p<0.05)