A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography

Robin E. Bonomi,Vadim Popov,Swatabdi Kamal,Shreya Potukutchi,Aleksandr Shavrin,Xin Lu,Nashaat Turkman,Ren Shyan Liu,Thomas J. Mangner,Juri G. Gelovani

A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography

2018

Robin E. Bonomi
Vadim Popov
Swatabdi Kamal
Shreya Potukutchi
Aleksandr Shavrin
Xin Lu
Nashaat Turkman
Ren Shyan Liu
Thomas J. Mangner
Juri G. Gelovani

Purpose The purpose of this study was to develop a SIRT2-specific substrate-type radiotracer for non-invasive PET imaging of epigenetic regulatory processes mediated by SIRT2 in normal and disease tissues.

Keywords:

Radiology
Medicine
Positron emission tomography
SIRT2
Molecular imaging
Nuclear medicine
pet imaging

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