Development of Post-Infarct Active Cardiac-Targeted Drug Delivery System by Liposomes with Sialyl Lewis X in Rabbits

presence of cAMP, Ca2+ spark frequency was much higher in KI than in WT saponin-permeabilized cardiomyocytes, whereas it was largely reversed by co-addition of CaM-Gly-Ser-His. Conclusions: In response to PKA phosphorylation, CaM binding affinity to the CPVT-associated mutant RyR2 was markedly decreased. Correction of the reduced binding affinity of CaM to the mutant RyR2 inhibits aberrant Ca2+ release.