Metal‐Free [4+2] Annulation of Arylalkynes with tert‐Butyl Nitrite through C(sp2)H Oxidation to Assemble Benzo[e][1,2]oxazin‐4‐ones
2015
A metal-free radical-mediated [4+2] annulation of internal arylalkynes with tert-butyl nitrite (t-BuONO) is presented for the synthesis of benzo[e][1,2]oxazin-4-ones through the addition of t-BuONO across the C C triple bond, hydration, isomerization and aromatic C(sp(2)) H oxidation cascades. The O-18-labeling experiment shows that two oxygen atoms in the product system are from water.
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