Synthesis of a Ring‐Scission Analogue of Neplanocin A as a Potential Inhibitor of S‐Adenosylhomocysteine Hydrolase.

The ring scission analogue of neplanocin A (1), acycloneplanocin A (2), as a potential S-adenosylhomocysteine hydrolase inhibitor was synthesized via the reductive cleavage of 2′,3′-O-isopropylideneadenosine (3) by DIBALH.