Relation of VEGF gene 936* T/C polymorphism to primary hepatocellnlar carcinoma

Objective To investigate the relation of VEGF gene 936* T/C polymorphism to pri-mary hepatocellular carcinoma. Methods Polymerase chain reaction-restriction fragment length poly-morphism (PCR-RFLP) was employed to study the VEGF 936* T/C genotypes in patients with pri-mary hepatoeellular carcinoma and healthy controls. Results There was no significant difference in the frequency of VEGF 936* C/C genotype or C allele between the patients and healthy controls (gen-otype P=0.275; allele χ2 =0.877,P=0.349). The C/C genotype or C allele in patients with tumor diameter≥8 cm (66.7% and 82.0%) were more frequently found than in those with tumor diameter<8 cm (40.0% and 65.0%), there was significant difference (C/C genotype χ2 =4. 722,P=0.029;C allele χ2 = 5.393,P:0.020). Conclusion VEGF 936* C/C genotype or Callele is not related to the development of primary hepatocellular carcinoma, but they both are related to the growth of the carci-noma. Key words: Carcinoma,hepatocellular; VEGF; Genetic polymorphism