Significance of detecting alpha-fetoprotein and soluble intercellular adhesion molecule-1 in the diagnosis of primary hepatocellular carcinoma

Objective To enhance the final diagnosis rate of primary hepatocellular carcinoma by detecting alpha-fetoprotein and soluble intercellular adhesion molecule-1.Methods One hundred and seventy-four patients with liver disease including 48 cases of primary hepatocellular carcinoma,18 cases of liver metastatic carcinoma,38 cases of liver benign tumor,42 cases of hepatic cirrhosis,30 cases of hepatitis and other 46 cases of normal controls were determined the sera alpha-fetoprotein and soluble intercellular adhesion molecule-1 with fluorescent enzyme linked immunosorbent assay and double antibody enzyme linked immunosorbent assay.Results Combined detection of alpha-fetoprotein and soluble intercellular adhesion molecule-1 enhanced the sensitivity of primary hepatocellular carcinoma diagnosis to 84% and the accuracy to 87%,higher than those of detection of any single tumor marker,and obviously reduced the rate of missed diagnosis.Conclusion The combined detection of two markers has clinical value in primary hepatocellular carcinoma.