Synthesis and Antimicrobial Evaluation of Novel 10H-phenothiazines, their Sulfones and Ribofuranosides

The present work refers the synthesis of novel substituted 10H-phenothiazines via Smiles rearrangement. Substituted 10H-phenothiazines are synthesized by the reaction of 2aminobenzenethiols and O-halonitrobenzenes. These synthesized phenothiazines undergoes oxidation when treated with 30% H2O2 in glacial acetic acid yielded 10Hphenothiazine-5,5-dioxides (sulfones). Further, when former were reacted with β-D-ribofuranose-1-acetate-2,3,5tribenzoate yields new ribofuranosides. These compounds were screened for their in vitro antimicrobial (antibacterial and antifungal) vitalities and exhibited promising results. The structural elucidation of synthesized compounds ensured on the basis of their elemental and spectral studies.