Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

Daniela M. Santos,Lorena Pantano,Gina Pronzati,Paula Grasberger,Clemens K. Probst,Katharine E. Black,Jillian J. Spinney,Lida P. Hariri,Royale Nichols,Yufei Lin,Michael Bieler,Peter Seither,Paul Leslie Nicklin,David Wyatt,Andrew M. Tager,Benjamin D. Medoff

Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

2020

Daniela M. Santos
Lorena Pantano
Gina Pronzati
Paula Grasberger
Clemens K. Probst
Katharine E. Black
Jillian J. Spinney
Lida P. Hariri
Royale Nichols
Yufei Lin
Michael Bieler
Peter Seither
Paul Leslie Nicklin
David Wyatt
Andrew M. Tager
Benjamin D. Medoff

Idiopathic pulmonary fibrosis (IPF) is a lung disease with limited therapeutic options characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. Yes asso...

Keywords:

Cancer research
Fibroblast
Hippo signaling pathway
Immunology
Lung
lung disease
HMG-CoA reductase
Pathological
Fibrosis
Idiopathic pulmonary fibrosis
Biology

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