Expression and Relativity of Cyclooxgenase-2 and Nuclear Factor κB in Rat Lung Tissue of Acute Lung Injury

【Objective】To observe expression and relativity of cyclooxgenase-2 and NF-κB in rat lung tissue and discuss the mechanism of NF-κB in acute lung injury.【Methods】The SD rats were injected lipopolysaccharide to establish the model of acute lung injury.Blood gas and wet/dry weight ratio(W/D) of lung were measured.The expression of cyclooxgenase-2 and nuclear factorκB were measured by immunohistochemical method.【Results】The PaO2 of rats in acute lung injury group significantly decreased compared with natural group.W/D increased in acute lung injury group(P0.05).Cyclooxgenase-2 and nuclear factorκB expressed a little in plasm in normal rats lung.But cyclooxgenase-2 expressed massively in rats lung tissue of acute lung injury.at the same time,the expression of nuclear factor κB transfered from plasm to nucleus.The correlation between them were high(r=0.924).【Conclusion】The expression of cyclooxgenase-2 and nuclear factorκB significantly increases in acute lung injury.They are highly correlated.