Anti-interferon alfa antibodies

Anti-IFN-a antibody comprising (A) at least one light chain or a fragment thereof comprising the following CDRs: (a) L1 of the formula RASQSVSTSSYSYMH (SEQ ID NO: 7); (b) L2 of the formula YASNLES (SEQ ID NO: 8); and (c) L3 of the formula QHSWGIPRTF (SEQ ID NO: 9); and (B) at least one heavy chain or a fragment thereof comprising the following CDRs: (a) H1 of the formula GYTFTEYIIH (SEQ ID NO: 10); (b) H2 of the formula SINPDYDITNYNQRFKG (SEQ ID NO: 11); and (c) H3 of the formula WISDFFDY (SEQ ID NO: 12); whose antibody binds and neutralizes a biological activity of at least the IFN-a, IFN-a1, IFN-a2, IFN-a4, IFN- subtypes a5, IFN-a8, IFN-a10, and IFN-a21.