Liver, Rejection and Tolerance

Innovative advances in the immunologic understanding of the relative resistance of the transplanted liver to rejection have continuously performed in the past decade as the results of experimental and clinical studies. Whereas mechanisms of the tolerogenic role of the liver were underlined, many evidences appeared that antibody mediated rejection (AMR) was probably not so negligible that we historically thought in liver transplantation (LT). This review will address to the spectrum of the mechanism of cellular and humoral liver rejection, the mechanisms of tolerance, as specific and not specific properties of the liver, and the immunomodulatory role of the liver in the combined solid organ transplantation.