A pharmacological evaluation of antidiarrhoeal activity of leaves extract of Murraya koenigii in experimentally induced diarrhoea in rats

Abstract Objective To evaluate anti-diarrhoeal activity of aqueous and alcoholic extract of the leaves of Murraya koenigii ( M. koenigii )by using models of castor oil induced diarrhoea, charcoal meal test and PGE 2 induced diarrhoea. Methods Alcoholic extract (400 mg/kg) and aqueous extract (200 mg/kg) of leaves of Murraya koenigii were used with loperamide as standard. Albino Wistar rats of both sexes weighing between 150–250 g were used for the anti-diarrhoeal activity. Results The result suggested that it could act centrally and inhibit the PGE 2 to give anti-diarrhoeal effects. Result of charcoal meal test also suggested its anti-muscarnic activity. Conclusions These findings indicate that aqueous extract of the leaves of M. koenigii displays good anti-diarrhoeal activity, corroborating the folk use of M. koenigii preparations and contributing for its pharmacological validation.