Dissociation of the diurnal variation of aldosterone and cortisol in anephric subjects

Dissociation of the diurnal variation of aldosterone and cortisol in anephric subjects. Diurnal variation of plasma aldosterone and cortisol concentration in man was studied in 13 anephric subjects and 7 normal subjects. All subjects were ambulatory and active throughout the study except during an 8-hour sleep period. Six anephric subjects received Kayexalate® (sodium polystyrene sulfonate) during the studies to prevent potassium accumulation and increase in plasma potassium concentration. Diurnal variation of plasma aldosterone concentration with peak and nadir concentrations at 12:00 noon and 12:00 midnight respectively was demonstrated in the studies on normal subjects. Changes in plasma aldosterone concentration were not significantly correlated with changes in plasma cortisol concentration but were highly correlated with changes in PRA (P Dissociation des variations nycthemerales de l'aldosterone et du cortisol chez les sujets anephriques. Les variations nycthemerales de l'aldosterone et du cortisol plasmatiques chez l'homme ont ete etudiees chez 13 sujets anephriques et 7 sujets normaux. Tous les sujets etaient ambulatoires excepte pendant une periode de sommeil de 8 heures. Six sujets anephriques receivaient du Kayexalate® (sodium polystyrene sulfonate) afin d'empecher une accumulation de potassium et une augmentation de la kaliemie. Des variations nycthemerales de l'aldosteronemie avec un pic et un nadir a midi et minuit, respectivement, ont ete observees chez les sujets normaux. Les modifications de l'aldosteronemie ne sont pas significativement correlees avec les modifications du cortisol plasmatique mais tres correlees avec celles de PRA (P