One-Pot Desymmetrizing Hydroformylation/Carbonyl Ene Cyclization Process: Straightforward Access to Highly Functionalized Cyclohexanols.

Rapid access to highly functionalized alkylidene cyclohexanols through a one-pot desymmetrizing hydroformylation/carbonyl ene cyclization starting from simple bisalkenylcarbinols is reported. Mechanistic insight into the carbonyl ene reaction is given, highlighting the importance of hyperconjugative substituent effects.