Специфичность регуляторной популяции ревматоидного фактора

Rheumatoid factor subset detected by agglutination techniques employing rat IgG-coated tanned erythrocytes as antigen is involved in autoimmunity regulation in collagen-induced arthritis. Specificity of regulatory rheumatoid factor subset was unknown. We have found out that regulatory rheumatoid factor subset recognizes neoantigens in Fc fragments of homologous IgG induced by papain cleavage or thermal aggregation of IgG. Generally used rabbit IgG does not bear antigenic group for this rheumatoid factor.