Research progress of apoptosis regulatory gene GRIM-19

Genes associated with retinoid-interferon mortality-19(GRIM-19)is one of the apoptosis-related genes induced by retinoid-interferon,is screened by Angell and others.It is located at 19p13.1 of human chromosome as a component of mitochondrial complex Ⅰ.It can specifically bind to STAT3 to inhibit the expression of target gene and cell growth through down-regulating transcription activity of STAT3.In addition,GRIM-19 can interact with GW112 and NOD2.The studies at home and abroad on the expression of GRIM-19 in renal cell carcinoma and other urologic neoplasms,colorectal cancer and thyroid carcinoma have proposed that GRIM-19 may be a novel tumor suppressor,biological marker for evaluating therapeutic effect and potential target for gene treatment. Key words: GRIM-19; Apoptosis; Tumor suppressor