[Chemotherapy by combination of low-dose CPT-11 and PSK in an elderly man with liver metastasis from gastric cancer].

: We attempted a new regimen of low-dose CPT-11 and PSK against a high age man with liver metastasis from gastric cancer. CPT-11 was administered at 20 mg/m2/day x 2/week, and PSK was given orally 3.0 g/day daily, respectively. Serum CEA level decreased gradually and almost reached normal limits (130 to 3.0 ng/ml). The tumor was reduced more than 50% at 13 weeks after the start of chemotherapy, when it had been continued for more than 8 weeks. There were no adverse effects and this regimen has been continued for more than 20 weeks without missing a week. These results suggest that the combination of low-dose CPT-11 and PSK has fewer side effects even in an elderly patient and may induce not only tumor shrinkage but also a prolonged time to progression.