Chronic glomerulonephritis in two horses

Summary Two middle-aged horses with chronic glomerulonephritis and renal insufficiency are described. Both horses had a history of dullness, inappetence, lethargy and weight loss during the monthprior to presentation. Physical examination revealed thin horses with pale mucus membranes and generalized subcutaneous edema. Routine hematology and serum biochemistry detected anemia, hypoalbuminemia, hypercalcemia, hyperkalemia and profound azotemia in both horses. Urinalyses revealed low urine specific gravities and proteinuria. The diagnosis of chronic glomerulonephritis was confirmed by microscopic examination and both horses had kidneys with prominent glomeruli which wherethickened by an amorphous, eosinophilic material.