Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus.

Priya Saju,Naoko Murata-Kamiya,Takeru Hayashi,Yoshie Senda,Lisa Nagase,Saori Noda,Keisuke Matsusaka,Sayaka Funata,Akiko Kunita,Masayuki Urabe,Yasuyuki Seto,Masashi Fukayama,Atsushi Kaneda,Masanori Hatakeyama

Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus.

2016

Priya Saju
Naoko Murata-Kamiya
Takeru Hayashi
Yoshie Senda
Lisa Nagase
Saori Noda
Keisuke Matsusaka
Sayaka Funata
Akiko Kunita
Masayuki Urabe
Yasuyuki Seto
Masashi Fukayama
Atsushi Kaneda
Masanori Hatakeyama

A host SHP1 phosphatase dephosphorylates and antagonizes the function of the Helicobacter pylori virulence factor CagA. EBV co-infection dampens SHP1 expression, leading to CagA hypervirulence.

Keywords:

CagA
Epstein–Barr virus
Virulence factor
SHP1 Phosphatase
Virology
Biology
Helicobacter pylori
Antigen
Protein tyrosine phosphatase
Phosphorylation
Carcinogenesis

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