神祕果萃取物對人類癌症（皮膚癌）抑制之研究

The purpose of this study is to survey the inhibition activities of Synsepolun dulcificum on human cancer cells, especially on skin cancer. The fruit of S. dulcificum was extracted with methanol (MeOH) and CHCl3 respectively, and evaluate their effects on inhibiting human cancer cells. This was the first time to analyze the bioactivities of this plant species. The data of antiproliferative effects of S. dulcificum extracts on human skin, liver, lung, prostate, cervical, bone bladder, and breast cancer cell lines were also investigated. Interestingly, through MTT cell viability assay, S. dulcificum extracts showed strong inhibition activities only on the proliferation of melanoma cell lines. We detected their inhibition effects on various human cancer cells and found extracts of S. dulcificurn showed strong inhibition activities. Its IC50 is 72.7/49.4 t g/ml on skin cancer cells (A375.S2/MeWo). From these experiments, we believed that extracts from S. dulcificum were potentially potent new medical cosmetology agents, with anti-skin cancer activities.