Homozygous intragenic deletion of type I hexokinase gene causes lethal hemolytic anemia of the affected fetus.

The type I hexokinase (HK-I) deficiency is a rare red cell enzymopathy associated with hereditary nonspherocytic hemolytic anemia. To date, only 16 affected families have been reported.[1][1] We report here prenatal diagnosis and molecular analysis of a Japanese family of HK deficiency. The proband'