EFFECT OF MESOXALATE ON INSULIN CONTENT OF PANCREAS

A definite daily dose of calcium mesoxalate was orally given to rats, and to young and adult dogs, for long periods and change in pancreatic insulin content was investigated.1. When 100mg/kg of calcium mesoxalate was daily given to rats for 1, 3, and 6 months, pancreatic insulin content was increased, most prominently in the 3 months group, becoming 1.5 times that of the control.2. When daily doses of 10mg/kg and 50mg/kg of calcium mesoxalate were given to young dogs for 2 months pancreatic insulin content was increased to 2 times the control level, without any difference by sex.3. When daily doses of 50mg/kg and 200mg/kg of calcium mesoxalate were given to adult dogs for 1 and 2 months, pancreatic insulin content was increased in the groups of the both doses for 1 month, especially prominently in the group of 200mg/kg for 1 month, attaining 2.5 times the control level. However, there was no difference from the control in the group of 50mg/kg for 2 months.