Celiac disease: pathways for diagnosis

Celiac disease is a chronic autoimmune disease, diagnosed in all age groups, associated with intestinal malabsorption and increasingly frequent extra-intestinal manifestations. Its clinical diagnosis depends on the close clinical, laboratory, and morphological correlation. The clinical suspicion leads to highly sensitive and specific serologic tests; however, the intestinal biopsy remains as a reference test, guided by endoscopy, which reveals villous atrophy in the intestinal mucosa.