Effect of Ginkgo biloba extract on the devolopment of gastric precancerous lesions and its antioxidant activity in Rats

Purpose To investigate the effects of Ginkgo biloba extract on gastric precancerous lesions and its antioxidant activity in Wistar rats.Methods 80 Wistar rats(4 weeks old) were randomly divided into four groups:control group,model group,low and high dose groups.100 μg/mL MNNG was used to feed rats to make animal models of gastric precancerous lesions(20 weeks),and low/high dose groups were lavaged with Ginkgo biloba extract in 0.5 mg/kg and 1.5 mg/kg per day respectively.After 30 weeks,rats were killed.We studied histopathological changes of gastric mucosa,nucleus-glandular index(ING),and index of structure atypism(ISA) in these rats.Serum and gastric tissue total superoxide dismutase /malondialdehyde(T-T-SOD/MDA) were also determined.Results Compared with model group,the incidence of mild to severe metaplasia,dysplasia,ISA,ING of intervention groups were significantly lower than model group(P0.01﹚.And Ginkgo biloba extract could increase the activity of T-T-SOD and decrease the content of MDA(P0.01).Conclusions Ginkgo biloba extract possesses a high inhibiting action on oxygen free radicals,effectively intervened in the development of gastric precancerous lesions in rats.