Ремоделирование костной ткани при несовершенном остеогенезе: выясненные и невыясненные вопросы, перспективы их решения

It is reported about results of study of bone tissue remodeling in imperfect osteogenesis by means of determination of level of markers of bone metabolism of the 3rd generation in 34 patients and the 4th generation — in 22 patients. The performed analysis of the level of bone markers revealed the increased activity of all chains of the bone turnover in this disease but the existing disorders depended on the disease kind. It was found out that in all cases in general increased activity of all chains of the bone turnover the processes of bone formation (osteogenesis) were the most intense. The authors give their own explanation of such pattern of the disorders: the organism «wants» to form the larger amount of bone tissue in response to its structural and functional deficiency. But the response to the formation of increased quantity of deficient tissue is the increased osteoresorption.