Catalyst -free and catalytic Friedel–Crafts alkylations of indoles in Solkane® 365mfc, an environmentally benign alternative solvent
2011
Solkane® 365mfc is a proven environmentally benign alternative solvent for catalyst-free Friedel–Crafts (F–C) alkylations of indoles with trifluoropyruvate and glyoxylate. Their enantioselective variants are also achieved by virtue of the high-affinity of fluorous cinchona alkaloids catalysts to Solkane® 365mfc to provide F–C adducts in excellent yields with good to excellent ees (up to 96% ee).
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