Evaluation of Analgesic and CNS Depressant Activities of Grewia Paniculata in Swiss albino Mice

Grewia paniculata (Family: Malvaceae) used to treat inflammation, pain, fever, wounds and also in psychological disorders. The present study was designed to investigate the analgesic and CNS depressant activities of different crude extract of Grewia paniculata. The analgesic activity was evaluated by using acetic-acid induced writhing, hot plate and tail immersion tests and the CNS depressant activity was examined by observing the reduction of locomotor and exploratory activities in the thiopental induced sleeping time, hole cross and open field tests in mice at the doses of 250 and 500 mg/kg, b.w. For analgesic and CNS depressant activity Diclofenac sodium (25 mg/kg i.p), Aspirin (100 mg/kg p.o), Morphine (5 mg/kg i.p) and Diazepam (1 mg/kg i.p) were used as reference drug, respectively. All the extract displayed significant analgesic effect (P<0.05-0.001) in acetic acid and heat induced pain models in a dose dependent manner. The extract prolonged the latency period to the thermal stimuli in both hot plate and tail immersion test. The spontaneous motor activity was decreased by (P<0.001) by all natural products in both hole cross and open field test. Statistical studies revealed that all the extracts prolong the duration of the thiopental sodium induced sleeping time in mice. Altogether, these results suggest that all the extracts of Grewia paniculata possesses potent analgesic and CNS depressant properties, which support its use in traditional medicine and suggesting that the plant should be further investigated for its pharmacological active natural products.