Clinical characteristics and prognosis of 26 cases of combined hepatocellular carcinoma and cholangiocarcinoma

Objective To investigate the clinical manifestations, imaging features and prognosis of mixed liver cancer. Methods The clinical and pathological data of 26 patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) pathologically diagnosed after liver resection were retrospectively analyzed, and the relevant factors affecting the prognosis were statistically analyzed. Results Of the 26 cHCC-CC patients, 19 were on background of chronic viral hepatitis, including 17 chronic viral hepatitis B and 2 chronic viral hepatitis C. There were 18 cases having AFP≥20ng/ml, 9 cases were with carbohydrate antigen 199 (CA199)≥37U/ml, and 5 cases with carcinoembryonic antigen (CEA)≥5ng/ml. The 1 -, 3 -, and 5-year postoperative survival rates were 68.8%, 34.4%, and 17.4%. Multivariate analysis showed that serum CA199≥37U/ ml(χ2=5.687, P=0.019) was an independent risk factor for patients′ survival. Conclusion Most cHCC-CC is found in association with chronic viral hepatitis. Serum CA199≥37U/ml is an independent risk factor affecting patients survival. Key words: Carcinoma, hepatocellular; Prognosis; Survival analysis