Antifibrotic agent, pirfenidone, inhibits pancreatic stellate cells and tumor-stromal interaction in pancreatic cancer

s / Pancreatology 13 (2013) e1–e94 e4 greatly accelerates pancreatic cancer development in the conditional KrasG12Dmouse model. This model and findings will provide the basis for more robust studies attempting to unravel the mechanisms underlying the cancer-promoting properties of obesity.